Stabilization of G protein-coupled receptors by point mutations

• Main Authors: Franziska eHeydenreich (Author), Ziva eVuckovic (Author), Milos eMatkovic (Author), Dmitry eVeprintsev (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors (GPCRs) are flexible integral membrane proteins involved in transmembrane signaling. Their involvement in many physiological processes makes them interesting targets for drug development. Determination of the structure of these receptors will help to design more specific...