Functional peroxisomes are required for β-cell integrity in mice

• Main Authors: Ritesh Kumar Baboota (Author), Abhijit Babaji Shinde (Author), Katleen Lemaire (Author), Marc Fransen (Author), Stefan Vinckier (Author), Paul P. Van Veldhoven (Author), Frans Schuit (Author), Myriam Baes (Author)
• Format: Book
• Published: Elsevier, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Peroxisomes play a crucial role in lipid and reactive oxygen species metabolism, but their importance for pancreatic β-cell functioning is presently unknown. To examine the contribution of peroxisomal metabolism to β-cell homeostasis in mice, we inactivated PEX5, the import receptor for...