PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma

• Главные авторы: Jing-Wei Zhou (Автор), Juan-Juan Tang (Автор), Wei Sun (Автор), Hui Wang (Автор)
• Формат: ‌
• Опубликовано: BMC, 2019-03-01T00:00:00Z.
• Предметы: article
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Abstract Background Endometrial carcinoma represents one of the most common cancer types of the female reproductive tract. If diagnosed at an early stage, the 5-year survival rate is promising. However, recurrence and chemoresistance remain problematic for at least 15% of the patients. In the presen...