Permeation-enhancing effects and mechanisms of O-acylterpineol on isosorbide dinitrate: mechanistic insights based on ATR-FTIR spectroscopy, molecular modeling, and CLSM images

• Autori principali: Yan Li (Autore), Chunyan Wang (Autore), Jian Wang (Autore), Tianzhe Chu (Autore), Linlin Zhao (Autore), Ligang Zhao (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The present study aimed to evaluate the penetration activity of O-acylterpineol derivatives both in vitro and in vivo, and to investigate the enhancing mechanism of O-acylterpineol derivatives which were synthesized by α-terpineol and fatty acid. The promoting activities on the isosorbide dinitrate...