Synthesis and Biological Evaluation of Novel Fusidic Acid Derivatives as Two-in-One Agent with Potent Antibacterial and Anti-Inflammatory Activity

• Main Authors: Borong Tu (Author), Nana Cao (Author), Bingjie Zhang (Author), Wende Zheng (Author), Jiahao Li (Author), Xiaowen Tang (Author), Kaize Su (Author), Jinxuan Li (Author), Zhen Zhang (Author), Zhenping Yan (Author), Dongli Li (Author), Xi Zheng (Author), Kun Zhang (Author), Weiqian David Hong (Author), Panpan Wu (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fusidic acid (FA), a narrow-spectrum antibiotics, is highly sensitive to various Gram-positive cocci associated with skin infections. It has outstanding antibacterial effects against certain Gram-positive bacteria whilst no cross-resistance with other antibiotics. Two series of FA derivatives were s...