An optimal combination of four active components in Huangqin decoction for the synergistic sensitization of irinotecan against colorectal cancer

• Main Authors: Hongyan Zhou (Author), Dingxin Hu (Author), Xian Zhao (Author), Siyuan Qin (Author), Qiyao Nong (Author), Yuan Tian (Author), Zunjian Zhang (Author), Haijuan Dong (Author), Pei Zhang (Author), Fengguo Xu (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Irinotecan (CPT-11) is a first-line treatment for advanced colorectal cancer (CRC). Four components (baicalin, baicalein, wogonin, and glycyrrhizic acid) derived from Huangqin Decoction (HQD) have been proven to enhance the anticancer activity of CPT-11 in our previous study. Obj...