Biophysics, Pathophysiology and Pharmacology of Ion Channel Gating Pores

• Main Authors: Adrien eMoreau (Author), Pascal eGosselin-Badaroudine (Author), Mohamed eChahine (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voltage sensor domain (VSDs) are a feature of voltage gated ion channel (VGICs) and voltage sensitive proteins. They are composed of four transmembrane (TM) segments (S1 to S4). Currents leaking through VSDs are called omega or gating pore currents.<br/>Gating pores are caused by mutations of...