Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats

• Main Authors: Yachao Zhao (Author), Zhiwei Jia (Author), Shanshan Huang (Author), Yaohong Wu (Author), Longgang Liu (Author), Linghan Lin (Author), Deli Wang (Author), Qing He (Author), Dike Ruan (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The functions of mesenchymal stem cells (MSCs) appear to decline with age due to cellular senescence, which could reduce the efficacy of MSCs-based therapies. Recently, MSCs have been identified in the nucleus pulposus, which offers great potential for intervertebral disc (IVD) repair. However, this...