Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress

• Main Authors: Anfal Al-Mass (Author), Pegah Poursharifi (Author), Marie-Line Peyot (Author), Roxane Lussier (Author), Emily J. Levens (Author), Julian Guida (Author), Yves Mugabo (Author), Elite Possik (Author), Rasheed Ahmad (Author), Fahd Al-Mulla (Author), Robert Sladek (Author), S.R.Murthy Madiraju (Author), Marc Prentki (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The recently identified glycerol-3-phosphate (Gro3P) phosphatase (G3PP) in mammalian cells, encoded by the PGP gene, was shown to regulate glucose, lipid and energy metabolism by hydrolyzing Gro3P and to control glucose-stimulated insulin secretion (GSIS) in β-cells, in vitro. However, wh...