Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure

• Main Authors: Jiayao Chen (Author), Shuhong Kuang (Author), Jietao Cen (Author), Yong Zhang (Author), Zongshan Shen (Author), Wei Qin (Author), Qiting Huang (Author), Zifeng Wang (Author), Xianling Gao (Author), Fang Huang (Author), Zhengmei Lin (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk of fragility fractures. However, the specific mechanisms of HFD-induced osteoporosis are not fully understood. Our study shows that exposure to an HFD induces premature senescence in bone marrow m...