Potent Antidiabetic Effects of Rivoglitazone, a Novel Peroxisome Proliferator-Activated Receptor-γ Agonist, in Obese Diabetic Rodent Models

• Main Authors: Shoichi Kanda (Author), Ryutaro Nakashima (Author), Kanako Takahashi (Author), Jun Tanaka (Author), Junko Ogawa (Author), Tsuneaki Ogata (Author), Makoto Yachi (Author), Kazushi Araki (Author), Jun Ohsumi (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacological effects of rivoglitazone, a novel thiazolidinedione-derivative peroxisome proliferator-activated receptor (PPAR)-γ agonist, were characterized in vitro and in vivo. Rivoglitazone activated human PPARγ more potently compared with rosiglitazone and pioglitazone and had little effec...