Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII

• Κύριοι συγγραφείς: Shaik Mahammad Ghouse (Συγγραφέας), Kavyaraj Bahatam (Συγγραφέας), Andrea Angeli (Συγγραφέας), Gaurav Pawar (Συγγραφέας), Krishna Kartheek Chinchilli (Συγγραφέας), Venkata Madhavi Yaddanapudi (Συγγραφέας), Arifuddin Mohammed (Συγγραφέας), Claudiu T. Supuran (Συγγραφέας), Srinivas Nanduri (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours. Selective and potent inhibitors targeting carbonic anhydrase IX and XII reduce the activity of these isoforms in hypoxi...