Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII

• Main Authors: Shaik Mahammad Ghouse (Author), Kavyaraj Bahatam (Author), Andrea Angeli (Author), Gaurav Pawar (Author), Krishna Kartheek Chinchilli (Author), Venkata Madhavi Yaddanapudi (Author), Arifuddin Mohammed (Author), Claudiu T. Supuran (Author), Srinivas Nanduri (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours. Selective and potent inhibitors targeting carbonic anhydrase IX and XII reduce the activity of these isoforms in hypoxi...