Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model

• Main Authors: Ewelina Rojewska (Author), Katarzyna Ciapała (Author), Anna Piotrowska (Author), Wioletta Makuch (Author), Joanna Mika (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Neuropathic pain caused by a primary injury or dysfunction in the peripheral or central nervous system is a tremendous therapeutic challenge. Here, we have collected the first evidence from a single study on the potential contributions to neuropathic pain development by enzymes in the kynurenine pat...