SG-APSIC1137: 12-hydroxystearic acid upregulates skin antimicrobial peptides in skin models and provides long-lasting protection from bacterial challenge from a handwash formulation

• Main Authors: Morris Waskar (Author), Xuelan Gu (Author), Tingyan Mi (Author), Meenakshi Swaminathan (Author), Carol Vincent (Author), Rimpa Ghosh (Author), Chandraprabha Doraiswamy (Author), Amitabha Majumdar (Author)
• Format: Book
• Published: Cambridge University Press, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: We evaluated the role of 12-hydroxystearic acid (12HSA) in upregulating skin antimicrobial peptides (AMPs) in in vitro and ex vivo assays, and 12HSA provides long-lasting germ protection in vivo through a handwash formulation. Methods: In vitro assays were performed by treating skin cell...