The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations

• Main Authors: Qian Xiang (Author), Weidang Wu (Author), Nan Zhao (Author), Chuan Li (Author), Junyu Xu (Author), Lingyue Ma (Author), Xiaodan Zhang (Author), Qiufen Xie (Author), Zhuo Zhang (Author), Jiancheng Wang (Author), Weiren Xu (Author), Xia Zhao (Author), Yimin Cui (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin pharmacokinetics. In addition, we compared the fluvastatin pharmacokinetics differences between extended-release (ER) 80 mg tablet and immediate-release (IR) 40 mg capsule in terms of drug metabolis...