An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation
Objective: The loss of forkhead box protein O1 (FoxO1) signaling in response to metabolic stress contributes to the etiology of type II diabetes, causing the dedifferentiation of pancreatic beta cells to a cell type reminiscent of endocrine progenitors. Lack of methods to easily model this process i...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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Format: | Book |
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Elsevier,
2021-12-01T00:00:00Z.
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A1234.567 |
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