Hypoxia releases S-nitrosocysteine from carotid body glomus cells-relevance to expression of the hypoxic ventilatory response

• Main Authors: James M. Seckler (Author), Paulina M. Getsy (Author), Walter J. May (Author), Benjamin Gaston (Author), Santhosh M. Baby (Author), Tristan H. J. Lewis (Author), James N. Bates (Author), Stephen J. Lewis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have provided indirect pharmacological evidence that hypoxia may trigger release of the S-nitrosothiol, S-nitroso-L-cysteine (L-CSNO), from primary carotid body glomus cells (PGCs) of rats that then activates chemosensory afferents of the carotid sinus nerve to elicit the hypoxic ventilatory resp...