Deconvolution of synthetic mRNA expression: Nucleoside chemistry alters translatability

• Asıl Yazarlar: Hanieh Moradian (Yazar), Marko Schwestka (Yazar), Toralf Roch (Yazar), Manfred Gossen (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2024-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Recent technological advances in the production of in vitro transcribed messenger RNA (IVT‐mRNA) facilitate its clinical use as well as its application in basic research. In this regard, numerous chemical modifications, which are not naturally observed in endogenous mRNA, have been implemen...