Deconvolution of synthetic mRNA expression: Nucleoside chemistry alters translatability

• প্রধান লেখক: Hanieh Moradian (Author), Marko Schwestka (Author), Toralf Roch (Author), Manfred Gossen (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2024-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Recent technological advances in the production of in vitro transcribed messenger RNA (IVT‐mRNA) facilitate its clinical use as well as its application in basic research. In this regard, numerous chemical modifications, which are not naturally observed in endogenous mRNA, have been implemen...