A pyrexic effect of FGF21 independent of energy expenditure and UCP1

• Main Authors: Petr Zouhar (Author), Petra Janovska (Author), Sara Stanic (Author), Kristina Bardova (Author), Jiri Funda (Author), Blanka Haberlova (Author), Birgitte Andersen (Author), Martin Rossmeisl (Author), Barbara Cannon (Author), Jan Kopecky (Author), Jan Nedergaard (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Administration of FGF21 to mice reduces body weight and increases body temperature. The increase in body temperature is generally interpreted as hyperthermia, i.e. a condition secondary to the increase in energy expenditure (heat production). Here, we examine an alternative hypothesis: th...