Dysbiosis in pregnant mice induced by transfer of human vaginal microbiota followed by reversal of pathological changes in the uterus and placenta via progesterone treatment

• Main Authors: Gulin Ozcan (Author), Zeynep Gülçe Tanyolaç Talay (Author), Erxiati Paerhati (Author), Ozgur Can Eren (Author), Nilhan Coskun (Author), Deniz Sahin (Author), Iman Alnajjar (Author), Ozgur Albayrak (Author), Attila Gursoy (Author), Ozlem Keskin (Author), Ebru Celik (Author), Fusun Can (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objective The vaginal microbiota dysbiosis induces inflammation in the uterus that triggers tissue damage and is associated with preterm birth. Progesterone is used to prevent labor in pregnant women at risk of preterm birth. However, the mechanism of action of progesterone still needs to b...