Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells

• Main Authors: Freddy López-Contreras (Author), Matías Muñoz-Uribe (Author), Jorge Pérez-Laines (Author), Laura Ascencio-Leal (Author), Andrés Rivera-Dictter (Author), Antonia Martin-Martin (Author), Rafael A. Burgos (Author), Pablo Alarcon (Author), Rodrigo López-Muñoz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug,...