Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease

• Автори: Courtney R. Green (Автор), Roberto Bonelli (Автор), Brendan R.E. Ansell (Автор), Simone Tzaridis (Автор), Michal K. Handzlik (Автор), Grace H. McGregor (Автор), Barbara Hart (Автор), Jennifer Trombley (Автор), Mary M. Reilly (Автор), Paul S. Bernstein (Автор), Catherine Egan (Автор), Marcus Fruttiger (Автор), Martina Wallace (Автор), Melanie Bahlo (Автор), Martin Friedlander (Автор), Christian M. Metallo (Автор), Marin L. Gantner (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2023-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objectives: The non-essential amino acids serine, glycine, and alanine, as well as diverse sphingolipid species, are implicated in inherited neuro-retinal disorders and are metabolically linked by serine palmitoyltransferase (SPT), a key enzyme in membrane lipid biogenesis. To gain insight into the...