Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease

• Main Authors: Courtney R. Green (Author), Roberto Bonelli (Author), Brendan R.E. Ansell (Author), Simone Tzaridis (Author), Michal K. Handzlik (Author), Grace H. McGregor (Author), Barbara Hart (Author), Jennifer Trombley (Author), Mary M. Reilly (Author), Paul S. Bernstein (Author), Catherine Egan (Author), Marcus Fruttiger (Author), Martina Wallace (Author), Melanie Bahlo (Author), Martin Friedlander (Author), Christian M. Metallo (Author), Marin L. Gantner (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The non-essential amino acids serine, glycine, and alanine, as well as diverse sphingolipid species, are implicated in inherited neuro-retinal disorders and are metabolically linked by serine palmitoyltransferase (SPT), a key enzyme in membrane lipid biogenesis. To gain insight into the...