In vitro and in vivo human metabolism and pharmacokinetics of S‐ and R‐praziquantel

• Main Authors: Nyasha Nicole Kapungu (Author), Xueqing Li (Author), Charles Nhachi (Author), Collen Masimirembwa (Author), Roslyn Stella Thelingwani (Author)
• Format: Book
• Published: Wiley, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Racemic praziquantel (PZQ) is the drug of choice for the treatment of schistosomiasis. R‐Praziquantel (R‐PZQ) has been shown as the therapeutic form, whereas S‐PZQ is less efficacious and responsible for the bitter taste of the tablet. This study aimed at investigating the metabolism of R‐...