Dapagliflozin Promotes Neovascularization by Improving Paracrine Function of Skeletal Muscle Cells in Diabetic Hindlimb Ischemia Mice Through PHD2/HIF-1α Axis

• Hauptverfasser: Dyah Ari Nugrahaningrum (Verfasst von), Olivia Marcelina (Verfasst von), Caiping Liu (Verfasst von), Shourong Wu (Verfasst von), Vivi Kasim (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Schlagworte: article
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Diabetes mellitus is associated with a high risk of hindlimb ischemia (HLI) progression and an inevitably poor prognosis, including worse limb salvage and mortality. Skeletal muscle cells can secrete angiogenic factors, which could promote neovascularization and blood perfusion recovery. Thus, parac...