Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells

• Main Authors: Nikolaos Karantzelis (Author), Michalis Petropoulos (Author), Valeria De Marco (Author), David A. Egan (Author), Alexander Fish (Author), Evangelos Christodoulou (Author), David W. Will (Author), Joe D. Lewis (Author), Anastassis Perrakis (Author), Zoi Lygerou (Author), Stavros Taraviras (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replication and genomic instability. CDT1 is a critical fac...