The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets.

• Główni autorzy: Kezia C L Whatley (Autor), Gilda Padalino (Autor), Helen Whiteland (Autor), Kathrin K Geyer (Autor), Benjamin J Hulme (Autor), Iain W Chalmers (Autor), Josephine Forde-Thomas (Autor), Salvatore Ferla (Autor), Andrea Brancale (Autor), Karl F Hoffmann (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2019-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

<h4>Background</h4>Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. While this drug is safe, its inability to kill all schistosome lifecycle stages withi...