The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets.

• Main Authors: Kezia C L Whatley (Author), Gilda Padalino (Author), Helen Whiteland (Author), Kathrin K Geyer (Author), Benjamin J Hulme (Author), Iain W Chalmers (Author), Josephine Forde-Thomas (Author), Salvatore Ferla (Author), Andrea Brancale (Author), Karl F Hoffmann (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. While this drug is safe, its inability to kill all schistosome lifecycle stages withi...