Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms

• Main Authors: Quynh V. Ton (Author), Daniel Leino (Author), Sarah A. Mowery (Author), Nina O. Bredemeier (Author), Pascal J. Lafontant (Author), Allison Lubert (Author), Suman Gurung (Author), Janice L. Farlow (Author), Tatiana M. Foroud (Author), Joseph Broderick (Author), Saulius Sumanas (Author)
• Format: Book
• Published: The Company of Biologists, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing approach to generate a loss-of-function mutant in zebrafish col22...