Translational Pharmacokinetic/Pharmacodynamic Modeling and Simulation of Oxaliplatin and Irinotecan in Colorectal Cancer

• প্রধান লেখক: Jinwei Zhu (লেখক), Yicui Zhang (লেখক), Yixin Zhao (লেখক), Jingwei Zhang (লেখক), Kun Hao (লেখক), Hua He (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2023-09-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Despite the recent advances in this field, there are limited methods for translating organoid-based study results to clinical response. The goal of this study was to develop a pharmacokinetic/pharmacodynamic (PK/PD) model to facilitate the translation, using oxaliplatin and irinotecan treatments wit...