Formulation-dependent differences in paclitaxel distribution to anatomical sites relevant to chemotherapy-induced peripheral neuropathy

• Main Authors: Milda Girdenytė (Author), Yang Hu (Author), Aghavni Ginosyan (Author), Margareta Hammarlund-Udenaes (Author), Irena Loryan (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting adverse event observed in patients receiving paclitaxel, associated with initial pathological changes in the peripheral nervous system, i.e., distal nerves and dorsal root ganglia (DRG). The prevalence of CIPN in patien...