Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever.

• Main Authors: Lisa Oestereich (Author), Toni Rieger (Author), Melanie Neumann (Author), Christian Bernreuther (Author), Maria Lehmann (Author), Susanne Krasemann (Author), Stephanie Wurr (Author), Petra Emmerich (Author), Xavier de Lamballerie (Author), Stephan Ölschläger (Author), Stephan Günther (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Mice lacking the type I interferon receptor (IFNAR-/- mice) reproduce relevant aspects of Crimean-Congo hemorrhagic fever (CCHF) in humans, including liver damage. We aimed at characterizing the liver pathology in CCHF virus-infected IFNAR-/- mice by immunohistochemistry and employed the...