New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex

• Main Authors: Jean Guillon (Author), Marc Le Borgne (Author), Vittoria Milano (Author), Aurore Guédin-Beaurepaire (Author), Stéphane Moreau (Author), Noël Pinaud (Author), Luisa Ronga (Author), Solène Savrimoutou (Author), Sandra Albenque-Rubio (Author), Mathieu Marchivie (Author), Haouraa Kalout (Author), Charley Walker (Author), Louise Chevallier (Author), Corinne Buré (Author), Eric Largy (Author), Valérie Gabelica (Author), Jean-Louis Mergny (Author), Virginie Baylot (Author), Jacky Ferrer (Author), Yamina Idrissi (Author), Edith Chevret (Author), David Cappellen (Author), Vanessa Desplat (Author), Zsuzsanna Schelz (Author), István Zupkó (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines <b>12</b> and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines <b>13</b> are reported here in six steps starting from various halogeno-quinazoline-2,4-(1<i>H</i>,3<i>H&...