Cover Image

New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex

The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines <b>12</b> and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines <b>13</b> are reported here in six steps starting from various halogeno-quinazoline-2,4-(1<i>H</i>,3<i>H&...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jean Guillon (Author), Marc Le Borgne (Author), Vittoria Milano (Author), Aurore Guédin-Beaurepaire (Author), Stéphane Moreau (Author), Noël Pinaud (Author), Luisa Ronga (Author), Solène Savrimoutou (Author), Sandra Albenque-Rubio (Author), Mathieu Marchivie (Author), Haouraa Kalout (Author), Charley Walker (Author), Louise Chevallier (Author), Corinne Buré (Author), Eric Largy (Author), Valérie Gabelica (Author), Jean-Louis Mergny (Author), Virginie Baylot (Author), Jacky Ferrer (Author), Yamina Idrissi (Author), Edith Chevret (Author), David Cappellen (Author), Vanessa Desplat (Author), Zsuzsanna Schelz (Author), István Zupkó (Author)
Format:	Book
Published:	MDPI AG, 2023-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives
by: Jean Guillon, et al.
Published: (2020)

Synthesis and Antimalarial Evaluation of New 1,3,5-<i>tris</i>[(4-(Substituted-aminomethyl)phenyl)methyl]benzene Derivatives: A Novel Alternative Antiparasitic Scaffold
by: Sandra Albenque-Rubio, et al.
Published: (2023)

Design, Synthesis, and In Vitro Antimalarial Evaluation of New 1,3,5-<i>Tris</i>[(4-(Substituted-Aminomethyl)Phenoxy)Methyl]Benzenes
by: Sandra Albenque-Rubio, et al.
Published: (2024)

In vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol
by: Marcellino Rudyanto, et al.
Published: (2023)

Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
by: Megan McGrath, et al.
Published: (2019)

Asymmetric Phenyl Substitution: An Effective Strategy to Enhance the Photosensitizing Potential of Curcuminoids
by: Guglielmo Vesco, et al.
Published: (2022)

Synthesis of New Compounds Bis-(N-Naphthal) Phthalisoimid, Bis-(N-Phenyl) Phthalisoimid and Studying Thermal Stabilty and Bio Activity
by: Marwan Mohammed F. All-Heety
Published: (2009)

Synthesis, Anticancer, Antimicrobial and Antioxidant Potential of Novel 4-(Substituted phenyl-1,3,4-oxadiazol/thiadiazol-2-yl)-4-(4-substituted phenyl) Azetidin-2-One Derivatives
by: Davinder Kumar, et al.
Published: (2023)

Synthesis of 2- alkyl/phenyl -5-Substituted 1,3,4- Thiadiazoles
by: Khalid Daoud, et al.
Published: (2014)

Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
by: İlhami Gulçin, et al.
Published: (2017)

Polymerization capability of simplified dental adhesives with camphorquinone, phenyl-propanedione and bis-alkyl phosphine photoinitiators
by: Boniek Castillo Dutra Borges, et al.
Published: (2018)

Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors
by: Jehad Hamdy, et al.
Published: (2022)

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles
by: Yun HY, et al.
Published: (2015)

Tris(aminomethyl)phosphines and Their Copper(I) (Pseudo)halide Complexes with Aromatic Diimines-A Critical Retrospection
by: Radosław Starosta
Published: (2023)

Antimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs
by: El-Sayed WM, et al.
Published: (2013)

Antitumour activity of 1,1-bis-(pyrimidine-2,4-diono-1-il)-2-bromo-2-chloroethylenes substituted molecular complexes and bacterial lectin
by: E. V. Welchinska
Published: (2015)

Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors
by: Lin Zhang, et al.
Published: (2022)

Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives
by: Kim DH, et al.
Published: (2017)

Electrocardiographic Findings in Acutely and Chronically -infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569
by: Elen M. De Souza, et al.
Published: (2007)

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives
by: Muhammad Kazim Zargaham, et al.
Published: (2023)

Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569
by: Elen M. de Souza, et al.
Published: (2007)

Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569
by: Elen M. de Souza, et al.
Published: (2007)

Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives
by: Suleyman Akocak, et al.
Published: (2019)

Synthesis, molecular structure and urease inhibitory activity of novel bis-Schiff bases of benzyl phenyl ketone: A combined theoretical and experimental approach
by: Rashid Ahmad, et al.
Published: (2023)

Novel 4-substituted phenyl-2,2'-bichalcophenes and aza-analogs as antibacterial agents: a structural activity relationship
by: Hussin WA, et al.
Published: (2013)

Synthesis of novel 3-benzyl-2-phenyl-4(5H)-(substituted phenylhydrazino)-1, 3-oxazolidines and their antihyperglycemic activity
by: T Panneerselvam
Published: (2011)

The psycho- and neurotropic profiling of novel 3-(N-R,R'-aminomethyl)-2-methyl-1H-quinolin-4-ones in vivo
by: Illya M. Podolsky, et al.
Published: (2018)

Synthesis and cytotoxic evaluation of substituted 3-(3'-indolyl-/3'-pyridyl)-isoxazolidines and bis-indoles
by: Vishal Sharma, et al.
Published: (2012)

The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones
by: Yevhen Karpun, et al.
Published: (2021)

Synthesis of 3-phenyl-4-styryl and 3-phenyl-4-hydroxy coumarins
by: Shaima Ismaeel
Published: (2008)

Antimicrobial screening and one-pot synthesis of 4-(substituted-anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives
by: Neelima Goel, et al.
Published: (2014)

New Complexes of Cobalt(II) Containing Mixed Ligands {Acetylacetone Bis(semi-carbazone and Substituted Phenols}
by: Zuhoor F.Dawood, et al.
Published: (2005)

Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells
by: Giuseppe Forlani, et al.
Published: (2021)

Design, synthesis, molecular docking and anticonvulsant evaluation of novel 6-iodo-2-phenyl-3-substituted-quinazolin-4(3H)-ones
by: Mohamed-Kamal Ibrahim, et al.
Published: (2015)

Anti-inflammatory and antinociceptive evaluation of newly synthesized 4-(substituted ethanoyl) amino-3-mercapto-5-(4-methoxy) phenyl-1,2,4-triazoles
by: Neeraj Upmanyu, et al.
Published: (2011)

Synthesis and physical-chemical properties of 3-benzyl-8-(5-mercapto-4-phenyl-[1,2,4]-triazole-3-ylmethylthiomethyl)xanthine and its s-substituted derivatives
by: K. V. Аleksandrova, et al.
Published: (2015)

A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[<i>d</i>]thiazoles: In Vitro and In Silico Insights
by: YeJi Hwang, et al.
Published: (2022)

Isotemporal substitution effect of 24-hour movement behavior on the mental health of Chinese preschool children
by: Fang Li, et al.
Published: (2024)

Design and synthesis of some novel 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-(substituted)phenyl)acetamide derivatives for biological evaluation as anticonvulsant agents
by: Mohamed-Kamal Ibrahim, et al.
Published: (2013)

Synthesis of Some 1,4-Bis (Substituted 1,3,4-Oxadiazoles and 1,2,4-Triazoles) Benzene From Terephthalic Acid
by: K. Daoud, et al.
Published: (1999)