RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

• Main Authors: Noyonika Mukherjee (Author), Christopher J. Contreras (Author), Li Lin (Author), Kaitlyn A. Colglazier (Author), Egan G. Mather (Author), Michael A. Kalwat (Author), Nathalie Esser (Author), Steven E. Kahn (Author), Andrew T. Templin (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely understood. Receptor interacting protein kinas...