RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely understood. Receptor interacting protein kinas...

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Main Authors: Noyonika Mukherjee (Author), Christopher J. Contreras (Author), Li Lin (Author), Kaitlyn A. Colglazier (Author), Egan G. Mather (Author), Michael A. Kalwat (Author), Nathalie Esser (Author), Steven E. Kahn (Author), Andrew T. Templin (Author)
Format: Book
Published: Elsevier, 2024-02-01T00:00:00Z.
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