LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC

• Main Authors: Ruiyan Yuan (Author), Yang Li (Author), Bo Yang (Author), Zhaohui Jin (Author), Jiacheng Xu (Author), Ziyu Shao (Author), Huijie Miao (Author), Tai Ren (Author), Yang Yang (Author), Guoqiang Li (Author), Xiaoling Song (Author), Yunping Hu (Author), Xu'an Wang (Author), Ying Huang (Author), Yingbin Liu (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant expression of lysyl oxidase-like 1 (LOXL1) reportedly leads to fibrous diseases. Recent studies have revealed its role in cancers. In this study, we observed an elevated level of LOXL1 in the tissues and sera of patients with intrahepatic cholangiocarcinoma (ICC) compared with levels in non...