Heme-Iron-Induced Production of 4-Hydroxynonenal in Intestinal Lumen May Have Extra-Intestinal Consequences through Protein-Adduct Formation

• Main Authors: Julia Keller (Author), Sylvie Chevolleau (Author), Maria-Helena (Author), Estelle Pujos-Guillot (Author), Mylène Delosière (Author), Céline Chantelauze (Author), Charlotte Joly (Author), Florence Blas- (Author), Isabelle Jouanin (Author), Denys Durand (Author), Fabrice Pierre (Author), Laurent Debrauwer (Author), Vassilia Theodorou (Author), Françoise Guéraud (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Some epidemiological studies show that heme iron consumption, in red meat, is associated to the development of several chronic diseases, including cancers and cardio-metabolic diseases. As heme iron intestinal absorption is finely regulated, we hypothesized that heme iron may act indirectly, through...