Increasing pro-survival factors within whole brain tissue of Sprague Dawley rats via intracerebral administration of modified valproic acid

Neural tissue exposure to valproic acid (VPA) increases several pro-survival phospho-proteins that can be used as biomarkers for indicating a beneficial drug response (pAktSer473, pGSK3βSer9, pErk1/2Thr202/Tyr204). Unfortunately, targeting VPA to neural tissue is a problem due to severe asymmetrical...

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Main Authors: Ryan C. Bates (Author), Bradley J. Stith (Author), Karen E. Stevens (Author)
Format: Book
Published: Elsevier, 2015-08-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available