Tumor Treating Fields (TTFields) Induce Cell Junction Alterations in a Human 3D In Vitro Model of the Blood-Brain Barrier

Tumor Treating Fields (TTFields) Induce Cell Junction Alterations in a Human 3D In Vitro Model of the Blood-Brain Barrier

In a recent study, we showed in an in vitro murine cerebellar microvascular endothelial cell (cerebEND) model as well as in vivo in rats that Tumor-Treating Fields (TTFields) reversibly open the blood-brain barrier (BBB). This process is facilitated by delocalizing tight junction proteins such as cl...

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Main Authors: Ellaine Salvador (Author), Theresa Köppl (Author), Julia Hörmann (Author), Sebastian Schönhärl (Author), Polina Bugaeva (Author), Almuth F. Kessler (Author), Malgorzata Burek (Author), Ralf-Ingo Ernestus (Author), Mario Löhr (Author), Carsten Hagemann (Author)
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Published: MDPI AG, 2023-01-01T00:00:00Z.
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