Integrated dataset of screening hits against multiple neglected disease pathogens.

• Main Authors: Solomon Nwaka (Author), Dominique Besson (Author), Bernadette Ramirez (Author), Louis Maes (Author), An Matheeussen (Author), Quentin Bickle (Author), Nuha R Mansour (Author), Fouad Yousif (Author), Simon Townson (Author), Suzanne Gokool (Author), Fidelis Cho-Ngwa (Author), Moses Samje (Author), Shailja Misra-Bhattacharya (Author), P K Murthy (Author), Foluke Fakorede (Author), Jean-Marc Paris (Author), Clive Yeates (Author), Robert Ridley (Author), Wesley C Van Voorhis (Author), Timothy Geary (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these h...