Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor against Pathophysiological Decline of Lung Function

• Main Authors: Haruka Fujikawa (Author), Yuki Sakamoto (Author), Natsuki Masuda (Author), Kentaro Oniki (Author), Shunsuke Kamei (Author), Hirofumi Nohara (Author), Ryunosuke Nakashima (Author), Kasumi Maruta (Author), Taisei Kawakami (Author), Yuka Eto (Author), Noriki Takahashi (Author), Toru Takeo (Author), Naomi Nakagata (Author), Hiroshi Watanabe (Author), Koji Otake (Author), Yasuhiro Ogata (Author), Naoko H. Tomioka (Author), Makoto Hosoyamada (Author), Tappei Takada (Author), Keiko Ueno-Shuto (Author), Mary Ann Suico (Author), Hirofumi Kai (Author), Junji Saruwatari (Author), Tsuyoshi Shuto (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The oxidant/antioxidant imbalance plays a pivotal role in the lung. Uric acid (UA), an endogenous antioxidant, is highly present in lung tissue, however, its impact on lung function under pathophysiological conditions remains unknown. In this work, pharmacological and genetic inhibition of UA metabo...