Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies

• Main Authors: Faten Farouk (Author), Ayman Abo Elmaaty (Author), Ahmed Elkamhawy (Author), Haytham O. Tawfik (Author), Radwan Alnajjar (Author), Mohammed A. S. Abourehab (Author), Mohamed A. Saleh (Author), Wagdy M. Eldehna (Author), Ahmed A. Al‐Karmalawy (Author)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and provoke antitumor potential. Herein, molecular docking studies were used to investigate the binding interactions of 138 antibiotics against t...