Rapid and scalable plant-based production of a cholera toxin B subunit variant to aid in mass vaccination against cholera outbreaks.

Rapid and scalable plant-based production of a cholera toxin B subunit variant to aid in mass vaccination against cholera outbreaks.

INTRODUCTION: Cholera toxin B subunit (CTB) is a component of an internationally licensed oral cholera vaccine. The protein induces neutralizing antibodies against the holotoxin, the virulence factor responsible for severe diarrhea. A field clinical trial has suggested that the addition of CTB to ki...

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Main Authors: Krystal Teasley Hamorsky (Author), J Calvin Kouokam (Author), Lauren J Bennett (Author), Keegan J Baldauf (Author), Hiroyuki Kajiura (Author), Kazuhito Fujiyama (Author), Nobuyuki Matoba (Author)
Format: Book
Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
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