Potential Pitfalls of the Humanized Mice in Modeling Sepsis

• Main Authors: Krzysztof Laudanski (Author), Michael Stentz (Author), Matthew DiMeglio (Author), William Furey (Author), Toby Steinberg (Author), Arpit Patel (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Humanized mice are a state-of-the-art tool used to study several diseases, helping to close the gap between mice and human immunology. This review focuses on the potential obstacles in the analysis of immune system performance between humans and humanized mice in the context of severe acute inflamma...