Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing

• Main Authors: Jaime I. Davila (Author), Pritha Chanana (Author), Vivekananda Sarangi (Author), Zachary C. Fogarty (Author), S. John Weroha (Author), Ruifeng Guo (Author), Ellen L. Goode (Author), Yajue Huang (Author), Chen Wang (Author)
• Format: Book
• Published: BMC, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background DNA polymerase epsilon (POLE) is encoded by the POLE gene, and POLE-driven tumors are characterized by high mutational rates. POLE-driven tumors are relatively common in endometrial and colorectal cancer, and their presence is increasingly recognized in ovarian cancer (OC) of end...