Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster

• Main Authors: Jo E. Lewis (Author), Chloe Monnier (Author), Hayley Marshall (Author), Maxine Fowler (Author), Rebecca Green (Author), Scott Cooper (Author), Aristeidis Chiotellis (Author), Jeni Luckett (Author), Alan C. Perkins (Author), Tamer Coskun (Author), Andrew C. Adams (Author), Ricardo J. Samms (Author), Francis J.P. Ebling (Author), Kostas Tsintzas (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both lowered caloric intake and increased energy expenditure. Previous resea...