Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model

• मुख्य लेखकों: Cheng Cui (लेखक), Miao Zhang (लेखक), Xueting Yao (लेखक), Siqi Tu (लेखक), Zhe Hou (लेखक), Valerie Sia Jie En (लेखक), Xiaoqiang Xiang (लेखक), Jing Lin (लेखक), Ting Cai (लेखक), Ning Shen (लेखक), Chunli Song (लेखक), Jie Qiao (लेखक), Shun Zhang (लेखक), Haiyan Li (लेखक), Dongyang Liu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic (PBPK) model for predicting tissue distribution of CQ and apply it to optimize dosage regimens, a PBPK model, with para...