Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model

• Main Authors: Cheng Cui (Author), Miao Zhang (Author), Xueting Yao (Author), Siqi Tu (Author), Zhe Hou (Author), Valerie Sia Jie En (Author), Xiaoqiang Xiang (Author), Jing Lin (Author), Ting Cai (Author), Ning Shen (Author), Chunli Song (Author), Jie Qiao (Author), Shun Zhang (Author), Haiyan Li (Author), Dongyang Liu (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic (PBPK) model for predicting tissue distribution of CQ and apply it to optimize dosage regimens, a PBPK model, with para...