Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model

• Główni autorzy: Hans-Soenke Jans (Autor), Xiao-Hong Yang (Autor), Dion R Brocks (Autor), Piyush Kumar (Autor), Melinda Wuest (Autor), Leonard I Wiebe (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Purpose: Pharmacokinetic (PK) data are generally derived from blood samples withdrawn serially over a defined period after dosing. In small animals, blood sampling after dosing presents technical difficulties, particularly when short time intervals and frequent sampling are required. Positron emissi...