Improved Treatment Outcomes by Using Patient Specific Drug Combinations in Mammalian Target of Rapamycin Activated Advanced Metastatic Cancers

• Main Authors: Timothy Crook (Author), Darshana Patil (Author), Andrew Gaya (Author), Nicholas Plowman (Author), Sewanti Limaye (Author), Anantbhushan Ranade (Author), Amit Bhatt (Author), Raymond Page (Author), Dadasaheb Akolkar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Activation of the mTOR signaling pathway is ubiquitous in cancers and a favourable therapeutic target. However, presently approved mTOR inhibitor monotherapies have modest benefits in labeled indications while poor outcomes have been reported for mTOR inhibitor monotherapy when administe...