The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs

• Main Authors: Meng Li (Author), Betty C. A. M. van Esch (Author), Paul A. J. Henricks (Author), Gert Folkerts (Author), Johan Garssen (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Background and Aim: Previously, we found that short chain fatty acids (SCFA) inhibit LPS or TNFα-induced endothelial inflammatory responses and excessive vascular cell adhesion molecule-1 (VCAM-1) expression, two important steps in the development of atherosclerosis. However, the mechanisms involved...