Physiologically‐Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam

• Main Authors: Hannah Britz (Author), Nina Hanke (Author), Anke‐Katrin Volz (Author), Olav Spigset (Author), Matthias Schwab (Author), Thomas Eissing (Author), Thomas Wendl (Author), Sebastian Frechen (Author), Thorsten Lehr (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study provides whole‐body physiologically‐based pharmacokinetic models of the strong index cytochrome P450 (CYP)1A2 inhibitor and moderate CYP3A4 inhibitor fluvoxamine and of the sensitive CYP1A2 substrate theophylline. Both models were built and thoroughly evaluated for their application in dr...